For decades, clinical trials have followed a centralized model. Participants travel to dedicated clinical sites—hospitals, research centers, or specialized facilities—for all study activities including screening, treatment administration, and follow-up visits.
While this approach offers direct oversight and control, it also creates significant challenges: geographic limitations, high costs, participant burden, and ultimately, slower enrollment timelines.
Decentralized clinical trials (DCTs) flip the traditional model by bringing study activities directly to participants. Instead of requiring site visits, DCTs use technology to collect data remotely:
Continuous biometric data collection through smartwatches and health trackers participants already own.
Video consultations replace in-person appointments for check-ins and assessments.
Validated questionnaires delivered through mobile apps capture patient-reported outcomes.
Study products shipped directly to participants, eliminating pharmacy visits.
Geographic barriers disappear when participation doesn't require travel. Rural populations, working parents, and those with mobility challenges can all participate.
Lower participant burden means fewer dropouts. Studies show DCTs can reduce dropout rates by 30% or more compared to traditional trials.
Data collected in participants' natural environments may better reflect real-world product performance than controlled clinical settings.
Parallel enrollment across unlimited locations accelerates study completion without compromising data quality.
The choice between centralized and decentralized isn't always binary. Many modern studies use hybrid approaches that combine elements of both—perhaps requiring an initial in-person screening but conducting follow-up remotely.
For consumer health products, supplements, and wellness interventions, decentralized methodologies often make the most sense. The outcomes being measured (sleep quality, stress levels, energy) are inherently personal and best captured in participants' daily lives.