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Verified Evidence Study for the Enhanced Brew | Reputable Health
RCT Case Study

Verified Evidence Study for the Enhanced Brew

How a functional coffee brand used a three-arm randomized controlled trial and continuous wearable biometrics to generate clinically-verified, marketing-ready sleep evidence.

Before: Raw Trial Data

Spreadsheets. PDFs. No story.

After: Claimable Evidence

The Challenge

The brand behind the Enhanced Brew had a loyal customer base and a product people loved—but needed more than testimonials. They required rigorous, controlled clinical evidence to substantiate sleep and wellness claims, satisfy retailers, and stay ahead of FTC scrutiny.

🔬

This three-arm RCT provides the strongest controlled evidence to date for the sleep and wellbeing benefits of the functional coffee studied. The dual convergence of significant subjective and objective sleep improvements is the headline finding of this study.

Reputable Health Research Team — Final Clinical Report, 2026

Turning Customers into Verified Proof

1

The Input

189 enrolled participants wore Oura Ring continuously and consumed their assigned beverage daily for 8 weeks across three parallel arms.

2

The Capture

Reputable's HIPAA-secure platform collected 20,000+ daily wearable data points alongside validated PROMIS-calibrated PRO surveys at three timepoints.

3

The Output

Significant sleep findings were transformed into verified, FTC-compliant marketing claims and a publication-ready clinical report.

The Key Findings

The Enhanced Brew was the only arm to show statistically significant improvements in both subjective sleep quality and objective wearable biometrics—a dual confirmation no control group matched.

🌙

Sleep Refreshingness

Patient-Reported Outcome · PRO Survey

"Significant improvement by Day 56—no change at midpoint, then meaningful gain—consistent with the cumulative adaptogenic mechanism of lion's mane."

p = 0.014 · Statistically Significant
⌚

Sleep Efficiency

Oura Ring Wearable · Objective Data

"The Enhanced Brew was the only arm to significantly improve sleep efficiency. Neither caffeinated coffee nor decaf control showed any meaningful change."

+1.02pp · p = 0.009 **
😴

Time Awake at Night

Oura Ring Wearable · Objective Data

"Participants in the Enhanced Brew arm spent significantly less time awake during the night by end of study—nearly 8 fewer minutes of wakefulness per night."

−7.7 min · p = 0.008 **
⚡

Fatigue Reduction

PROMIS Survey · Directional Trend

"Directional improvement in fatigue (−0.216) trending more favorably than caffeinated coffee, possibly reflecting smoother energy delivery via L-theanine co-administration."

−0.216 Change Score · Positive Trend
🌿

GI Comfort Reports

Spontaneous Qualitative · Multiple Participants

"Multiple participants independently reported reduced IBS symptoms, improved bowel regularity, and less stomach discomfort—without being prompted by survey questions."

Qualitative Signal · Individual Responder Effects
🛡️

Safety Profile

Adverse Events · 8-Week Period

"Only 11.4% of Enhanced Brew participants reported any adverse experiences over the full 8-week study. No serious adverse events were observed in any study arm."

88.6% Adverse-Experience Free

Sleep Claims

Dual PRO + wearable verified

Oura Ring Data

Continuous biometric tracking

Retailer Decks

Data-backed sales slides

RCT Report

Publication-ready findings

Objective Wearable Biometrics

Oura Ring captured sleep signals continuously across all 129 completers. Only the Enhanced Brew arm reached statistical significance on objective sleep metrics—both at p<0.01.

Sleep Efficiency
+1.02pp
Enhanced Brew · Baseline → Day 56
p = 0.009 **
Time Awake / Night
−7.7 min
−464.7 seconds per night average
p = 0.008 **
Deep Sleep
+61 sec
Enhanced Brew arm (non-significant)
p = 0.312
REM Sleep
+85 sec
Enhanced Brew arm (non-significant)
p = 0.218
Oura Ring continuous tracking
HIPAA-secure data collection
20,000+ daily data points

Real Participants, Real Reports

Selected spontaneous qualitative reports from Enhanced Brew study completers. These are illustrative examples—not representative of the full sample.

⚡

Energy & Focus

Enhanced Brew Study Completer

"More energetic and easier to concentrate."

Energy · Focus · No Jitters
🌿

GI Calm & Comfort

Enhanced Brew Study Completer

"I felt more calm after drinking—not jittery like I do with other forms of caffeine. I also felt my GI health was better. I tend to sometimes have issues with symptoms of IBS and felt that these symptoms were better when I consumed the product."

GI Comfort · Calm Energy
🌱

GI Regularity

Enhanced Brew Study Completer

"I felt that my stomach issues became less noticeable and my bowel movements became more regular."

Stomach Comfort · Regularity
😌

No Stomach Pain

Enhanced Brew Study Completer

"Alert. No stomach pain with gastritis."

Alert · GI Tolerability
😴

Sleep & Digestion

Enhanced Brew Study Completer

"BM's were good! Deep sleep was also good."

Sleep Quality · GI Health
🔋

Appetite & Energy

Enhanced Brew Study Completer

"I had more energy throughout the day. My appetite was also curbed and I had less sugar cravings."

Energy · Appetite Control
~90%
Protocol Adherence Rate

Exceptional compliance across the 8-week study reflects Reputable's frictionless participant experience—powered by HIPAA-secure data collection, automated SMS and push notification reminders, and continuous Oura Ring syncing.

The Impact

Retail Ready

Armed with a three-arm RCT and verified biometric data to prove efficacy to buyers and close retail partnerships.

Regulatory Safety

Claims backed by dual-confirmed real-world evidence to mitigate FTC risk and stay compliant with FDA structure-function guidelines.

Speed to Market

From enrollment to verified, publication-ready clinical findings—in weeks, not the years of traditional research.

Ready to turn your customers into verified proof?

Stop guessing. Start proving. Get your verified assets in 90 days.